Association between Asp299Gly and Thr399Ile Polymorphisms in Toll-Like Receptor 4 Gene and Type 2 Diabetes Mellitus: Case-Control Study and Meta- Analysis

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Association between Asp299Gly and Thr399Ile Polymorphisms in Toll-Like Receptor 4 Gene and Type 2 Diabetes Mellitus: Case-Control Study and Meta-Analysis

Taís Silveira Assmann1,2, Natália Emerim Lemos1,2, Letícia de Almeida Brondani1,2, Rodrigo Carlessi1,2, Carmen Maldonado-Bernal3,4, Miguel Cruz3,4, Luis Henrique Canani1,2 and Daisy Crispim1,2* 1Endocrine Division, Hospital de Clínicas de Porto Alegre. Porto Alegre, Rio Grande do Sul, Brazil 2Postgraduate Program in Medical Sciences: Endocrinology, Universidade Federal do Rio Grande do Sul. Por...

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Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

BACKGROUND The pathogenesis of inflammatory bowel disease (IBD) involves interactions between the host genetic susceptibility, intestinal microflora and mucosal immune responses through the pattern recognition receptor. Polymorphisms in toll-like receptor 4 (TLR4) induce an aberrant immune response to indigenous intestinal flora, which might favor IBD development. In this study, we aimed to det...

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Role of Thr399Ile and Asp299Gly polymorphisms of toll-like receptor-4 gene in acute dental abscess

BACKGROUND Apical Periodontitis (AP) is an inflammatory disease that affects the tissues surrounding the root end of a tooth. The disease which is caused by endodontic infections presents in different clinical ways including development of an acute abscess. Recent studies have provided information suggesting role of a multitude of factors in pathogenesis of acute apical abscess (AAA). In this c...

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Absence of the toll-like receptor 4 gene polymorphisms Asp299Gly and Thr399Ile in Singaporean Chinese

Toll-like receptor 4 (TLR4) is the transuding subunit of lipopolysaccharide receptor and an important intracellular signal pathway of the innate immune response. Published data about the relationship between TLR4 mutations and atopy/asthma are not consistent. This study was performed to detect two commonly reported Asp299Gly and Thr399Ile polymorphisms in TLR4 gene in Singaporean Chinese and th...

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Association between IGF2BP2 Polymorphisms and Type 2 Diabetes Mellitus: A Case–Control Study and Meta-Analysis

BACKGROUND Genome-wide association studies (GWAS) found that IGF2BP2 rs4402960 and rs1470579 polymorphisms were associated with type 2 diabetes mellitus (T2DM) risk. Many studies have replicated this association, but yielded inconsistent results. MATERIALS AND METHODS A case-control study consisting of 461 T2DM patients and 434 health controls was conducted to detect the genetic susceptibilit...

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ژورنال

عنوان ژورنال: Journal of Diabetes & Metabolism

سال: 2018

ISSN: 2155-6156

DOI: 10.4172/2155-6156.1000449